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Shimbashi · DAY · Clinic · Tokyo · Est. MMXXVI

World Class Japanese Medicine,
Delivered Seamlessly.

Tokyo's leading centre for regenerative medicine, immunotherapy, and day surgery — now welcoming international patients from around the world.

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633+
Hernia Cases / Year
6+
Languages Available
1st
Intrathecal ADSC in Japan
8yr+
Long-Term Safety Data

Why Choose Us

Three Pillars of Distinction

Day Treatment
Day Treatment

No hospitalization required. Complete high-quality treatment in minimal stays — minimizing your travel cost and time away from home.

Cutting-Edge Medicine
Cutting-Edge Medicine

Regenerative medicine and immune cell therapy under Japan's Act on the Safety of Regenerative Medicine — among the world's most rigorous regulatory frameworks.

Prime Location
Prime Location

Minutes from Shimbashi Station in central Tokyo. Direct access from Haneda and Narita airports. Surrounded by world-class hotels.

Key Credentials
Anti-aging medicine, properly understood, is not the attempt to stop aging. It is the medicine of restoring, from within, the cellular capacity for repair, tissue homeostasis, neurological function, metabolic function, and immune function that decline with age.

Masayuki Okamura, MD

Director & CEO · Shimbashi DAY Clinic Tokyo

About the Clinic

A Medicine Founded on
Law, Science, and Care

Our Philosophy

To deliver Japan's most advanced medicine equally to patients from every country — with transparency, patient-centred care, and long-term follow-up as our foundation.

Shimbashi DAY Clinic Tokyo was established as a specialized centre for day-surgery inguinal hernia repair and has expanded into regenerative and anti-aging medicine under strict national authorization — combining surgical precision with cellular renewal under one roof.

Location6F Shimbashi NF Bldg., 1-15-7 Shimbashi, Minato-ku, Tokyo 105-0004
Access2 min walk from JR Shimbashi Station (Karasumori Exit)
AppointmentBy reservation only · Private consultation rooms
LanguagesJapanese · English · Chinese · Korean (others by arrangement)
Medical VisaInvitation letter & documentation support available
RegulatoryAct on the Safety of Regenerative Medicine (Class II) certified
👨‍⚕️
Dr. Masayuki Okamura — CEO & Clinic Director, Shimbashi DAY Clinic Tokyo
Masayuki Okamura, MD
CEO · Clinic Director · Board-Certified Anesthesiologist

Dr. Okamura is a board-certified anesthesiologist who serves as CEO and Director of Shimbashi DAY Clinic Tokyo. His unique dual expertise in perioperative safety and regenerative medicine positions the clinic at the intersection of surgical precision and cellular therapy — a combination exceptionally rare in Japan.

Under his direction, the clinic has accumulated several thousand inguinal hernia day-surgery cases and pioneered Japan's first legally authorized intrathecal administration of autologous adipose-derived stem cells — a milestone in the global development of regenerative neurology.

Anesthesiology Regenerative Medicine Anti-Aging Day Surgery

Medical Services

Three Areas of Expertise

All treatments are provided under Japan's national regulatory framework, with multilingual coordination throughout.

Regenerative Medicine
01
Service 01
Regenerative Medicine
Autologous ADSC Therapy

Adipose-derived stem cells harvested from your own body, cultured and administered intravenously and — uniquely in Japan — intrathecally to renew the body and brain from within.

Learn more →
Immunotherapy
02
Service 02
Immunotherapy
NK / NKT Cell Therapy

Cultured NK and NKT immune cells administered to strengthen systemic immunity, support cancer prevention, and promote healthy aging at the cellular level.

Learn more →
Inguinal Hernia Surgery
03
Service 03
Inguinal Hernia
Day Surgery

Laparoscopic repair under insurance or self-pay, completed on the day of visit. No hospitalization. Over 633 cases annually with an established safety record.

Learn more →
01

Regenerative Medicine — Autologous Adipose-Derived Stem Cell (ADSC) Therapy

Japan's most advanced cellular renewal — IV + intrathecal dual approach

What Is ADSC Therapy?

Mesenchymal stem cells harvested from your own adipose (fat) tissue are cultured to high purity and administered to restart your body's own repair programme. The ADSC does not merely replace damaged cells — it functions as a mobile biofactory, secreting growth factors, exosomes, and immunomodulatory molecules that simultaneously address multiple hallmarks of aging.

"The ADSC is not a cell that replaces a defective spot precisely; it functions as a mobile biofactory carrying layered information and resources."

The Dual Approach

RouteRolePer Session
Intravenous (IV)Whole-body renewal — inflammation, microcirculation, metabolism150 million cells
Intrathecal (IT)Central nervous system — cognition, neuroprotection, synaptic function50 million cells
6Sessions
¥30MFull Course
1.2BCells Total
8yr+Safety Record

Areas of Application

ADSC acts on at least 8 of the 12 Hallmarks of Aging (López-Otín et al., Cell 2013/2023).

  • Anti-aging & whole-body rejuvenation
  • Cognitive preservation & brain fog
  • Alzheimer's disease prevention
  • Parkinson's disease progression
  • Post-stroke recovery
  • Spinal cord injury
  • ALS / Multiple system atrophy
  • Arterial stiffness & metabolic health
  • Skin quality & hair restoration
  • Chronic fatigue & energy
  • Erectile dysfunction
  • Hormonal & autonomic balance
Japan Exclusive: Shimbashi DAY Clinic Tokyo is the sole institution in Japan legally authorized to administer autologous adipose-derived stem cells via the intrathecal route — delivering cells directly across the blood-brain barrier to the central nervous system.

Cell Quality — Grandsoul Nara CPC

  • Proprietary culture protocol — non-cryopreserved, high-viability (≥96%)
  • Xeno-free, animal-component-free culture
  • GMP-aligned QC including genetic stability testing (array CGH)
  • 8+ years of follow-up — no tumour formation reported

Four Key Mechanisms of Action

ADSC operates as a "mobile biofactory" — not replacing damaged cells, but reorganising the disease environment across four biological pathways simultaneously. This multi-layered approach cannot be replicated by standard pharmacotherapy.

1 · Neurotrophic Factor Secretion

BDNF, GDNF, NGF, NT-3 — homing to the site of neuronal injury, blocking the apoptosis cascade and sustaining dopaminergic neuron survival. CSF analysis shows NGF levels rising 100× within one week of intrathecal administration.

2 · Mitochondrial Recovery

Restores Complex I activity, reduces reactive oxygen species (ROS) overproduction, and normalises ATP synthesis — targeting the metabolic root of neurodegeneration rather than its downstream symptoms.

3 · Exosome Pathway — α-Synuclein Suppression

Exosomes (30–150 nm vesicles) enter neurons and suppress abnormal α-synuclein aggregation — the hallmark pathology of Parkinson's disease — via mRNA methylation regulation (FTO pathway). A cell-free mechanism unique to ADSC.

4 · Microglia Repolarisation

IL-10 and IL-4 secretion shifts microglia from M1 (pro-inflammatory) to M2 (neuroprotective) phenotype — silencing the chronic neuroinflammation cycle that accelerates disease progression in Parkinson's, ALS, and other neurodegenerative conditions.

Treatment Course & Flow

PhaseContent
Pre-visit (Online)Initial consultation with physician · Medical history review · Treatment plan & fee confirmation
Visit 1 — JapanFull pre-treatment examination (blood, CT, whole-body MRI, ECG) · Biological age baseline (TruDiagnostic™ + SystemAge™) · Adipose harvest (local anesthesia, 1–2.5 cm incision)
Visits 2–7 — JapanIV infusion (150M cells) + Intrathecal administration (50M cells) × each session · Continuous vital monitoring · Post-session observation
Follow-up (Online)Reviews at 1, 3, 6, 12 months · Biological age reassessment at 12 months

What's Included in the Standard Course

  • IV infusion (150M cells) + Intrathecal (50M cells) × 6 sessions — ~1.2 billion cells total
  • Pre-treatment examination: comprehensive blood panel, CT, whole-body MRI, ECG, abdominal ultrasound
  • Biological age assessment: TruDiagnostic™ epigenetic clock (Horvath / GrimAge / DunedinPACE) + Generation Lab SystemAge™ organ-system age including brain / neurological age
  • Parkinson's assessment battery: MDS-UPDRS Part I / II / III (OFF), Hoehn & Yahr staging, Schwab & England ADL Scale, PHQ-9 (depression), GAD-7 (anxiety), 3-axis accelerometry (tremor & gait)
  • All assessments repeated at 12 months — objective Before / After comparison delivered to patient and referring physician
  • Physician consultations: initial online + 6 in-clinic visits + 3 post-course online follow-ups
  • Adipose harvest surgery (local anaesthesia, 1–2.5 cm incision) — once only for the full course
  • Cell line storage: 2 years (extension available)
  • Multilingual coordination: English directly by physicians & nurses · Chinese / Korean via qualified interpreters · Sinhala concierge on staff
  • Shared Care coordination with your referring or primary neurologist — treatment data shared in writing after each session

Clinical Evidence — Key Publications

StudyDesignKey Finding
Ra et al. (2018)
J Clin Case Rep		 70 patients with neurological disorders incl. PD (age 52–89) · Up to 25 intrathecal injections · 8+ year follow-up Zero serious adverse events. No tumour formation or tumour marker elevation over 8 years. All side effects mild (back pain, headache) and resolved within 24 hrs.
Shigematsu et al. (2022)
Acta Neurol Scand		 3 PD patients with inadequate pharmacological control · ADSC IV × 5–6 sessions · 6-month observation MDS-UPDRS Part IV (motor complications) improved 7 → 0 in one case. FDG-PET confirmed normalisation of cerebral metabolism. Zero serious adverse events.
2024 Tokyo Real-World Data
Nature Cell / R Bio / Japan Angel Stem Cell · Press Conference, Nov 2024		 136 PD patients · 473 infusions (IV + IT combined) over 12 months Tremor elimination or marked reduction; gait stability / freezing improved; sleep and depression significantly improved. QOL recovery: "self-travel without wheelchair," "resumed drumming, golf, swimming," "using chopsticks without difficulty." Zero serious adverse events.

Large-scale RCTs for ADSC in Parkinson's disease are ongoing internationally (e.g. NCT04928287). The above represents published open-label and real-world evidence. All treatments at Shimbashi DAY Clinic are performed under Japan's national regulatory framework (Act on Safety of Regenerative Medicine, Class II).

Frequently Asked Questions

How many times do I need to visit Japan?
The standard course involves 7 visits to Japan over approximately 12 months: Visit 1 for pre-treatment examination and fat harvest, then Visits 2–7 for the 6 treatment sessions at intervals of 4–8 weeks. Follow-up consultations are available online.
Is the therapy safe? What are the side effects?
As an autologous transplant using your own cells, immune rejection is theoretically negligible. Reported side effects are mild and transient (low-grade fever, headache, post-puncture headache resolving with rest). In 8+ years of clinical data, no serious adverse events have been reported.
What is the fee?
The standard "Total Rejuvenation Master" course is ¥30,000,000 (inclusive of 10% consumption tax). This includes all 6 sessions, biological age measurements, comprehensive examination, and 2-year cell line storage. Visa support, airfare, and accommodation are available as separate options.
Do I need to speak Japanese?
Not at all. English is provided directly by physicians and nurses. Qualified medical interpreters are available for Chinese, Korean, and other languages. Our international coordinator will support you from inquiry through to post-treatment follow-up.
Is ADSC therapy specifically suitable for Parkinson's disease?
Yes. Unlike levodopa and DBS — which compensate for dopamine deficiency or electrically modulate abnormal circuits — ADSC therapy targets the disease process itself: neuroprotection of surviving dopaminergic neurons, suppression of α-synuclein aggregation, mitochondrial recovery, and reduction of chronic neuroinflammation. This is classified as Disease-Modifying Therapy (DMT). It is used alongside, not instead of, your current medications. The 2024 Tokyo real-world data (136 patients, 473 IV+IT infusions) reported meaningful improvements in tremor, freezing of gait, wearing-off, depression, and sleep quality — with zero serious adverse events. Patients are encouraged to discuss this therapy with their primary neurologist; our clinic provides written treatment data to support shared care.
02

Immunotherapy — NK Cell & NKT Cell Therapy

Activate your immune system from within

What Is Immune Cell Therapy?

NK (Natural Killer) and NKT (Natural Killer T) cells are key soldiers of innate immunity — capable of detecting and eliminating abnormal cells including cancer cells and virus-infected cells. As we age, the number and function of these cells decline. Immune cell therapy cultures and amplifies these cells from your own blood and returns them to your body at high concentration.

Treatment Menu

TreatmentIndication
NK Cell TherapyCancer prevention, infection prevention, immunity enhancement
NKT Cell TherapyAdvanced immune activation, various cancers

Key Benefits

  • Enhanced cancer surveillance
  • Infection resistance improvement
  • Adjunct cancer therapy support
  • Chronic fatigue reduction
  • Immune-mediated anti-aging
  • Improved post-treatment recovery
Immune cell therapy is understood as a complementary approach. We strongly encourage coordination with your primary physician. All treatment plans are reviewed individually during consultation.
Procedure
Blood collection → Cell separation → NK cell expansion & cultivation (approx. 3–4 weeks) → Administration
How many sessions are needed?
The number of sessions and cell count are determined individually based on your health goals and consultation results. Please contact us for details.
Can I combine this with ADSC therapy?
Yes. ADSC and immune cell therapy are complementary. Many patients choose a combined approach for both systemic renewal and immune activation.
03

Inguinal Hernia Day Surgery

Japan's proven excellence — completed on the day of your visit

Our Strength in Day Surgery

Shimbashi DAY Clinic Tokyo performs over 633 inguinal hernia repair cases per year under public health insurance — with several thousand cases of safe practice accumulated. This volume reflects both the expertise and the safety culture embedded in our daily practice.

Under the direction of a board-certified anesthesiologist, the clinic brings the rigour of perioperative management to every phase of care — from risk assessment through to post-operative follow-up.

ProcedureLaparoscopic repair (mesh technique)
AnesthesiaGeneral or local — determined by case
Surgery timeApprox. 30–60 minutes
Hospital stayDay visit — same-day discharge
Clinic stayApprox. 4 hours total (including recovery)
Post-surgery activityWalk out on your own — no dietary or activity restrictions; sightseeing and business engagements possible the same day
Language supportEnglish, Chinese, Korean coordinator available

Surgery Flow for International Patients

1
Online Pre-consultation
Medical history, symptom check, document preparation guidance
2
Day of Surgery — Arrival
Pre-operative examination, anesthesia explanation, informed consent
3
Surgery (30–60 min)
Laparoscopic repair under continuous anesthesiologist monitoring
4
Recovery Room (1–2 hrs)
Post-operative observation, vital monitoring, discharge check
5
Post-Discharge Follow-up
Online follow-up available after return to home country
When can I fly after surgery?
Flying timing depends on individual recovery and anesthesia type. Please consult your physician — we will advise a specific timeline during your pre-operative consultation.

For International Patients

Your Complete Journey,
Supported at Every Step

From your first inquiry in your home country to post-treatment follow-up after you return — our international team is with you throughout.

01
Step 01
Online Pre-Consultation (Free · Before Travel)

Contact us via our web form, WhatsApp, WeChat, or LINE. Our international coordinator will reply within 2 business days. An online video consultation (Zoom / Google Meet / WeChat Video) with our physician follows — free of charge.

02
Step 02
Treatment Plan & Cost Estimate

Your personalized treatment plan, detailed fee breakdown, and visit schedule are prepared and shared in writing. No surprise charges — all costs are confirmed before you travel.

03
Step 03
Medical Visa & Travel Arrangement

We issue the invitation letter, medical documentation, and treatment summary required for a Japanese medical visa application. Visa support, hotel, airport transfer, and concierge services are available as optional add-ons through our partner network.

04
Step 04
Visit Japan — Treatment

From airport arrival to clinic, our coordinator accompanies you. Multilingual staff at reception. Treatment delivered with continuous physician oversight. Translation of all documents into your language.

05
Step 05
After Your Return — Online Follow-Up

Scheduled video consultations at 1, 3, 6, and 12 months. Your progress is monitored; your questions are answered. Biological-age reassessment at 12 months provides objective data on your renewal.

Language & Medical Coordination Support

I
Languages Supported

English — directly by physicians & nurses
中文 (Chinese) — via qualified interpreters
한국어 (Korean) — via qualified interpreters
Sinhala — dedicated Sri Lanka concierge
Hindi, Vietnamese — arranged through agents

II
Medical Coordinator Role

Dedicated coordinator assigned from inquiry to post-return. Medical interpretation, document translation, airport-to-clinic arrangement, hotel coordination, and clinic liaison throughout your stay.

III
Document Support

Medical invitation letter for visa application. Diagnostic reports in multiple languages. Discharge summaries translated and delivered. Records retained for continuity with your home physician.

Optional Services

Japan Experience & Concierge

All services are optional, arranged through our partner network, and quoted individually at enquiry.

Private Cultural Programme
Japan Experience

Private Cultural Programme

Onsen, traditional crafts, Japanese cuisine, and scenic tours — privately arranged around your treatment schedule, seasonally curated to your interests.

View Plans ◇
Visa Application Support
Medical Visa

Visa Application Support

Invitation letter issued by the clinic. Full documentation prepared, submission and interview support via our partner.

USD 3,000
International Flights
Airfare

International Flights

Business or first-class booking arranged through our partner travel agency. VIP lane access at departure airports available on request.

Hotel in Tokyo
Accommodation

Hotel in Tokyo

Property selected to your preference of location, grade, and group size. Family and companion rooms coordinated together.

Private Transfer & Escort
Transport

Private Transfer & Escort

Airport arrival and departure escort. Private car, helicopter, or private jet within Japan. Clinic staff concierge on all non-clinic days.

Physician House Call
In-Stay Care

Physician House Call

Physician visits to your hotel for in-stay follow-up. Medical accompaniment on optional excursions available on request.

Companion & Attendant Support
Caregiver

Companion & Attendant Support

Full logistics for patients travelling with family or a caregiver — accommodation, transfers, and schedule coordination integrated.

All optional services are arranged through our partner network and quoted individually. Please indicate your preferences at the time of inquiry.

Fees & Payment

ADSC Therapy — Total Rejuvenation Master

IV 150M + Intrathecal 50M × 6 sessions · Examination, bio-age tests & 2yr cell storage included

¥30,000,000 incl. tax

NK / NKT Cell Therapy

Cell count & sessions determined individually

By consultation

Inguinal Hernia Day Surgery

Procedure & anesthesia type vary by case

By consultation

Initial Consultation

Online video consultation

Free of charge

All fees are presented in writing prior to treatment. No additional charges applied without prior explanation and consent.

Accepted Payment Methods

  • Cash (Japanese Yen)
  • Major credit cards — Visa, Mastercard, JCB, AMEX, Diners Club
  • International bank transfer (SWIFT / wire transfer)
  • Payment via referring agent or partner medical institution

Medical Insurance All treatments are private-pay (self-funded). We provide documentation for submission to international insurers or health plans where applicable. Please confirm coverage with your insurer before travel.

Access & Location

At the Heart of Tokyo —
Easy from Any Airport

Clinic Address

Address
6F Shimbashi NF Bldg., 1-15-7 Shimbashi, Minato-ku, Tokyo 105-0004, Japan
Telephone
+81-50-5527-1126
Email
info@1dc.jp
Nearest Station
JR Shimbashi Station — Karasumori Exit (approx. 2 min walk)

From the Airports

30min
Haneda Airport (HND)
Keikyu Line → Shinagawa → JR Yamanote to Shimbashi
Taxi / Limousine Bus: ~30–45 min
70min
Narita Airport (NRT)
Narita Express (N'EX) → Shimbashi direct
Limousine Bus: ~70–100 min

Clinic Location

Open in Google Maps →

Recommended Nearby Hotels

Shimbashi is centrally located with excellent hotel options for patients seeking comfortable accommodation during treatment. Our coordinator can assist with booking.

  • Walking distance from clinic recommended for session days
  • Wide selection from luxury to comfortable business hotels
  • Our coordinator provides tailored hotel recommendations based on your budget and group size

Accessibility

  • Elevator access to 6th floor — wheelchair and mobility-aid accessible
  • Private consultation rooms — no shared waiting area
  • Private entry and exit routes available on request for privacy

Why Japan

Four Elements,
Rarely Combined

Japan is one of the few countries where regenerative medicine whose safety and ethics are assured at the national level is delivered as part of routine clinical practice.

I
A National Framework of Safety & Ethics

Japan's Act on the Safety of Regenerative Medicine (2014) classifies all MSC therapy as Class II — requiring committee approval, ministry submission, accredited cell manufacturing, 10-year record retention, IRB review, and mandatory adverse event reporting. This is among the world's most rigorous frameworks.

II
Proprietary Cell Quality — Grandsoul Nara CPC

Cells are manufactured at Grandsoul Nara Cell Processing Facility, our joint venture partner. Non-cryopreserved, ≥96% viability, xeno-free culture in Class A–D cleanrooms, with GMP-aligned genetic stability verification. The gold standard for intrathecal-grade cell preparation.

III
Perioperative Safety — Anesthesiologist-Led

Our clinic is directed by a board-certified anesthesiologist — a discipline uniquely trained in risk assessment and acute response. The "culture of safety" cultivated in 633+ annual hernia surgeries is applied to every phase of regenerative medicine — from harvest to administration to long-term follow-up.

IV
Japan's Only Intrathecal ADSC Authorization

Shimbashi DAY Clinic Tokyo is the sole institution in Japan legally authorized to administer autologous adipose-derived stem cells via the intrathecal route — delivering cells directly to the central nervous system across the blood-brain barrier. Available, in this form, nowhere else in Japan.

Contact & Consultation

Begin Your Journey Today

Initial online consultation is free of charge. Our team replies within 2 business days in your preferred language.

Send an Inquiry

Other Ways to Reach Us

Email
info@1dc.jp
Phone / Direct Call
+81-50-5527-1126
WhatsApp
+81 90-3680-2470
LINE
ID near confirmation — use form
WeChat
ID near confirmation — use form
Response time: We aim to reply within 2 business days (Japan Standard Time). For urgent matters, please call directly.

Application Process

Step 1Submit inquiry through this form or contact your nearest authorized agent
Step 2Medical history review & scheduling — our coordinator contacts you
Step 3Online consultation with our physician — treatment plan & cost confirmed
Step 4Travel to Japan & begin treatment — full support throughout your stay